NoncoRNA Tutorial

Sep. 2019

[1] Overview

Non-coding RNAs refer to RNAs that do not encode proteins. But they pay important roles in cellular functions, and their deregulation are associated with a variety of human diseases, including neurodegenerative diseases and cancers. Substantial research is going on to reveal the functions of ncRNAs in drug resistant. To collect and annotate these data, we developed NoncoRNA, a manually curated database of experimentally supported non-coding RNA and drug target associations in cancer. Current version contains 5,568 ncRNAs and 154 drugs in 134 cancers. Each entry in the NoncoRNA contains detailed information on ncRNAs, drug, cancer, and other information.

The overview of the database is as followings:

[2] Browse

To browse ncRNA-drug-cancer association data in the database, please select the menu "Browse" (Figure 1). Users can browse all entries in two ways: by ncRNA, by cancer or by drug. Take a browse "glioma"-related ncRNAs as an example. To browse the entries for glioma, please click "Cancer" and select the "glioma" option. The browse result will be displayed in the right panel.

[3] Search

To search data in the database, please select the menu "Search".

In the NoncoRNA database, users can search all entries in three ways: search by ncRNA, search by drug or search by cancer. Detailed information shown in search results:

  • ncRNA information: ncRNA, detection method for ncRNA expression, ncRNA expression pattern, associator, host gene.
  • cancer information: cancer, species, tissue and/or cell line, a brief description of the ncRNA-drug target relationship in cancer.
  • other information: article title, journal, published time, PubMed ID.

[4] Download

To download data in the database, please select the menu "Download". The NoncoRNA provides two formats of downloadable file in TEXT and Excel formats, respectively.

[5] Submit

To submit data in the database, please select the menu "Submit". We will also encourage research scientists to submit the experimentally supported ncRNA-drug-cancer association. The users need to input their data into corresponding blanks and then submit the query. The submitted information in the future will be manually reviewed and then integrated into this database.

[5] Question and Answer

If you have any questions, suggestions and comments, please feel free to contact Dr. Jiang at jcl6688@163.com