ncRNA basic information
ncRNA ID:
MI0000091
ncRNA Database:
miRBase
ncRNA Name:
miR-33a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
real-time qRT-PCR
ncRNA Target Gene:
TWIST
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
OS patients who showed <90% tumor necrosis after neochemotherapy were defined as poor responders (chemoresistant), and those who showed ¡Ý90% tumor necrosis were defined as good responders (control). miRNA microarray analysis was carried out with a discovery cohort (n=12) of age-, sex- and tumor stage-matched chemoresistant and control OS patients.
Drug Response:
resistant
Cancer basic information
Cancer:
osteosarcoma
Tissue/Cell:
cell line (Saos-2, MG-63)
Other information
Title:
miR-33a is up-regulated in chemoresistant osteosarcoma and promotes osteosarcoma cell resistance to cisplatin by down-regulating TWIST.
Journal:
J Exp Clin Cancer Res
Published:
2014
PubMed ID:
24468065