ncRNA basic information
ncRNA ID:
MI0000272
ncRNA Database:
miRBase
ncRNA Name:
miR-182
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
TP53INP1
ncRNA Pathway:
miR-182/TP53INP1 signaling
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Real-time polymerase chain reaction and those of protein were by Western blot analysis. Lciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
hepatocellular carcinoma
Tissue/Cell:
cell line (HEK293, HepG2, HepG2-R)
Other information
Title:
Upregulated miR-182 increases drug resistance in cisplatin-treated HCC cell by regulating TP53INP1.
Journal:
Gene
Published:
2014
PubMed ID:
24447717