ncRNA basic information
ncRNA ID:
MI0000293
ncRNA Database:
miRBase
ncRNA Name:
miR-217
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
DNMT3A
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01254
Drug Name:
Dasatinib
Drug Method:
The expression levels of miRNA were determined by reverse transcription-polymerase chain reaction and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Methylation analysis by methylation-specific PCR,
Drug Response:
sensitive
Cancer basic information
Cancer:
Ph(+) leukemia
Tissue/Cell:
cell line (K562,K562DR)
Other information
Title:
Downregulation of miR-217 correlates with resistance of Ph(+) leukemia cells to ABL tyrosine kinase inhibitors.
Journal:
Cancer Sci
Published:
2014
PubMed ID:
24350829