ncRNA basic information
ncRNA ID:
MI0000255
ncRNA Database:
miRBase
ncRNA Name:
miR-30d
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
Real-time RT-PCR,qRT-PCR
ncRNA Target Gene:
beclin 1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Real-time RT-PCR and qRT-PCR .Those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. The ATC xenograft mouse model was used to idnentify the role of miR-30d .
Drug Response:
sensitive
Cancer basic information
Cancer:
anaplastic thyroid carcinoma
Tissue/Cell:
cell line (SW1736, 8305C )
Other information
Title:
Regulation of autophagy by miR-30d impacts sensitivity of anaplastic thyroid carcinoma to cisplatin.
Journal:
Biochem Pharmacol
Published:
2014
PubMed ID:
24345332