ncRNA basic information
ncRNA ID:
MI0000650
ncRNA Database:
miRBase
ncRNA Name:
miR-200c
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
Real Time RT-PCR
ncRNA Target Gene:
ZEB1,ZEB2,FN1,NTRK2,QKI,TUBB3
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name:
Paclitaxel
Drug Method:
The expression levels of miRNA were determined by Real Time RT-PCR . Luciferase activity assay was used to verify the target genes of miRNAs.Cell migration was detected by migration and invasion assay.
Drug Response:
sensitive
Cancer basic information
Cancer:
endometrial cancer
Tissue/Cell:
cell line (Hec50,EEC B37,MCF-7, T47D, ZR75, BT-474, MDA-MB-231, BT-549)
Other information
Title:
MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents.
Journal:
Mol Cancer Ther
Published:
2009
PubMed ID:
19435871