ncRNA basic information
ncRNA ID:
MI0000087
ncRNA Database:
miRBase
ncRNA Name:
miR-29a
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
MMP2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.Three online programs, miRanda, TargetScan and TarBase, were used in combination with previous reports, for predicting the target of miRNAs .Cell migration was detected by transwell invasion assay.Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic.
Drug Response:
resistant
Cancer basic information
Cancer:
oral squamous cell carcinoma
Tissue/Cell:
cell line (sSCC-4, SCC-9, SCC25)
Other information
Title:
MicroRNA-29a upregulates MMP2 in oral squamous cell carcinoma to promote cancer invasion and anti-apoptosis.
Journal:
Biomed Pharmacother
Published:
2014
PubMed ID:
24210072