ncRNA basic information
ncRNA ID:
MI0000289/MI0000269
ncRNA Database:
miRBase
ncRNA Name:
miR-181a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
PRKCD
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by quantitative real-time polymerase chain reaction and those of protein were by Western blot analysis.Assessment of cell viability and proliferation using the Cell Counting Kit-8 . Cell apoptosis was determined by assessing the activation of caspase-3 and caspase-7 . Flow cytometric analysis of cell cycle distribution .
Drug Response:
resistant
Cancer basic information
Cancer:
cervical squamous cell carcinoma
Tissue/Cell:
tissue and cell line (SiHa, Me180)
Other information
Title:
MicroRNA-181a enhances the chemoresistance of human cervical squamous cell carcinoma to cisplatin by targeting PRKCD.
Journal:
Exp Cell Res
Published:
2014
PubMed ID:
24183997