ncRNA basic information
ncRNA ID:
MI0000274
ncRNA Database:
miRBase
ncRNA Name:
miR-187
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
real-time quantitative RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined by real-time quantitative RT-PCR and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic.
Drug Response:
resistant
Cancer basic information
Cancer:
peripheral T-cell lymphoma
Tissue/Cell:
cell line (Jurkat, MOLT4, HUT78)
Other information
Title:
MicroRNA187 overexpression is related to tumor progression and determines sensitivity to bortezomib in peripheral T-cell lymphoma.
Journal:
Leukemia
Published:
2014
PubMed ID:
24104394