ncRNA basic information
ncRNA ID:
MIMAT0004778
ncRNA Database:
miRBase
ncRNA Name:
miR-508-5p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
real-time qRT-PCR
ncRNA Target Gene:
ABCB1 and ZNRD1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00541 (APRD00495)
Drug Name:
Vincristine
Drug Method:
The expression levels of miRNA were determined by real-time qRT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic.
Drug Response:
sensitive
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell line (SGC7901,SGC7901/VCR, SGC7901/ADR)
Other information
Title:
miR-508-5p regulates multidrug resistance of gastric cancer by targeting ABCB1 and ZNRD1.
Journal:
Oncogene
Published:
2014
PubMed ID:
23893241