ncRNA basic information
ncRNA ID:
MI0000476/MI0000455
ncRNA Database:
miRBase
ncRNA Name:
miR-138
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
FAK
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined byReal-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Cell migration was detected by invasion assay.
Drug Response:
sensitive
Cancer basic information
Cancer:
cancer
Tissue/Cell:
cell line
Other information
Title:
MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells.
Journal:
Anticancer Agents Med Chem
Published:
2014
PubMed ID:
23438844