ncRNA basic information
ncRNA ID:
MI0000342
ncRNA Database:
miRBase
ncRNA Name:
miR-200b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
Real-Time RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
Hedgehog pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00530 (APRD00951)
Drug Name:
Erlotinib
Drug Method:
Hh signaling was inhibited by specific siRNA and by GDC-0449, a small molecule antagonist of G protein coupled receptor smoothened in the Hh pathway. Not all NSCLC patients are likely to benefit from EGFR-TKIs and, therefore, cisplatin was used to further demonstrate a role of inhibition of Hh signaling in sensitization of resistant EMT cells. Specific pre- and anti-miRNA preparations were used to study the mechanistic involvement of miRNAs in drug resistance mechanism.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung adenocarcinoma
Tissue/Cell:
cell line (A549, H1299,A549M)
Other information
Title:
Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs.
Journal:
J Hematol Oncol
Published:
2013
PubMed ID:
24199791