ncRNA basic information
ncRNA ID:
MI0000289/MI0000269
ncRNA Database:
miRBase
ncRNA Name:
miR-181a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
Twist1
ncRNA Pathway:
miR-181a-Twist1 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Transwell was selected to test the invasive ability of the cells .Cell migration was assessed by wound-healing assay.
Drug Response:
sensitive
Cancer basic information
Cancer:
tongue squamous cell carcinoma
Tissue/Cell:
cell line (CAL27, SCC15)
Other information
Title:
miR-181a-Twist1 pathway in the chemoresistance of tongue squamous cell carcinoma.
Journal:
Biochem Biophys Res Commun
Published:
2013
PubMed ID:
24148247