ncRNA basic information
ncRNA ID:
MI0000778
ncRNA Database:
miRBase
ncRNA Name:
miR-370
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
FoxM1
ncRNA Pathway:
miR-370-FoxM1 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB04865
Drug Name:
Homoharringtonine
Drug Method:
The synergistic action between miR-370 and HHT was examined by flow cytometry. The effect of HHT on miR-370 expression was determined by quantitative RT-PCR (qRT-PCR). The expression of miR-370 and Forkhead box M1 (FoxM1) in 23 patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML-CP) and 10 patients with blast-crisis CML (CML-BP) as well as miR-370-targeted FoxM1 was determined by qRT-PCR and western blot analysis.
Drug Response:
sensitive
Cancer basic information
Cancer:
chronic myeloid leukemia
Tissue/Cell:
cell line (K562)
Other information
Title:
MiR-370 sensitizes chronic myeloid leukemia K562 cells to homoharringtonine by targeting Forkhead box M1.
Journal:
J Transl Med
Published:
2013
PubMed ID:
24148180