ncRNA basic information
ncRNA ID:
MI0000113
ncRNA Database:
miRBase
ncRNA Name:
miR-106a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
PTEN
ncRNA Pathway:
PTEN/Akt pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Quantitative real-time polymerase chain reaction (qRT-PCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. The CCK-8 assay was used to monitor the growth of the cells .
Drug Response:
resistant
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell line (SGC7901,SGC7901/DDP)
Other information
Title:
miR-106a confers cisplatin resistance by regulating PTEN/Akt pathway in gastric cancer cells.
Journal:
Acta Biochim Biophys Sin (Shanghai)
Published:
2013
PubMed ID:
24108762