ncRNA basic information
ncRNA ID: MIMAT0000425
ncRNA Database: miRBase
ncRNA Name: miR-130a-3p
ncRNA Type: miRNA
ncRNA Expression: up-regulated/down-regulated
ncRNA Method: qRT-PCR
ncRNA Target Gene: Bcl-2,XIAP
ncRNA Pathway: p53-dependent apoptosis-pathway
Evidence (ncRNA-drug): validated
drug basic information
Drug ID: DB00515 (APRD00359)
Drug Name: Cisplatin
Drug Method: The current study investigated the role of different expression levels of miR-130a-3p and miR-148a-3p on drug resistance and tumor biology in four esophageal squamous cell carcinoma cell lines.The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Apoptosis assays through flow cytometry.
Drug Response: sensitive
Cancer basic information
Cancer: esophageal squamous cell carcinoma
Tissue/Cell: cell line (KYSE-70, KYSE-140, KYSE-270 and KYSE-410)
Other information
Title: Complex role of miR-130a-3p and miR-148a-3p balance on drug resistance and tumor biology in esophageal squamous cell carcinoma
Journal: Sci Rep
Published: 2018
PubMed ID: 30510209