ncRNA basic information
ncRNA ID:
MI0000299
ncRNA Database:
miRBase
ncRNA Name:
miR-222
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
PTEN
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01248 (APRD00932)
Drug Name:
Docetaxel
Drug Method:
The expression levels of miRNA were determined by Real-time quantitative PCR (RT-qPCR) and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Cell apoptosis was determined using an Annexin-V-FITC apoptosis detection kit .
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF-7, MCF-7/Doc,MCF-7/Adr,MCF-7/S )
Other information
Title:
MiR-222 and miR-29a contribute to the drug-resistance of breast cancer cells.
Journal:
Gene
Published:
2013
PubMed ID:
23994196