ncRNA basic information
ncRNA ID:
MI0000113
ncRNA Database:
miRBase
ncRNA Name:
miR-106a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
RUNX3
ncRNA Pathway:
TGF-Beta family pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00541 (APRD00495)
Drug Name:
Vincristine
Drug Method:
The expression levels of miRNA were determined by quantitative real time PCR (qRT-PCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell line (SGC7901,SGC7901/ADR,SGC7901/VCR)
Other information
Title:
MicroRNA-106a induces multidrug resistance in gastric cancer by targeting RUNX3.
Journal:
FEBS Lett
Published:
2013
PubMed ID:
23932924