ncRNA basic information
ncRNA ID:
MI0000300
ncRNA Database:
miRBase
ncRNA Name:
miR-223
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
ABCB1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The role of miR-223 in hepatocellular carcinoma cells was detected using plasmid construct , real-time PCR, western blot, EGFP reporter assay, cell viability assay (WST-1 assay), silencing ABCB1 by siRNA transfection, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
hepatocellular carcinoma
Tissue/Cell:
cell line (Hep3B,HCC3, LM-6, SMMC7721,Huh-7, SK-Hep-1,HepG2, BEL-7402)
Other information
Title:
MiR-223 modulates multidrug resistance via downregulation of ABCB1 in hepatocellular carcinoma cells.
Journal:
Exp Biol Med (Maywood)
Published:
2013
PubMed ID:
23925649