ncRNA basic information
ncRNA ID:
MI0000102
ncRNA Database:
miRBase
ncRNA Name:
miR-100
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00541 (APRD00495)
Drug Name:
Vincristine
Drug Method:
The expression levels of miRNA were determined byy real-time quantitative PCR (RT-qPCR) . The amount of apoptosis was measured using the Annexin-V/propidium iodide staining method .MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
acute lymphocytic leukemia
Tissue/Cell:
cell line (HEK293T)
Other information
Title:
MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia.
Journal:
Leuk Res
Published:
2013
PubMed ID:
23915977