ncRNA basic information
ncRNA ID:
MI0002471
ncRNA Database:
miRBase
ncRNA Name:
miR-487a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
BCRP/ABCG2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01204 (APRD00371)
Drug Name:
Mitoxantrone
Drug Method:
The expression levels of miRNA were determined by QRT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Nude mouse xenograft model was used to identify the effect of miR-487 .
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF-7,MCF-7/MX)
Other information
Title:
MiR-487a resensitizes mitoxantrone (MX)-resistant breast cancer cells (MCF-7/MX) to MX by targeting breast cancer resistance protein (BCRP/ABCG2).
Journal:
Cancer Lett
Published:
2013
PubMed ID:
23879965