ncRNA basic information
ncRNA ID:
MI0000271
ncRNA Database:
miRBase
ncRNA Name:
miR-181c
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
PBX3,HSP90B1,NMT2 and RAD21
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00619 (APRD01028, EXPT02967, DB03261)
Drug Name:
Imatinib
Drug Method:
In the study, we performed miRNA microarray followed by RT-qPCR verification of 9 available diagnostic bone marrow core biopsies from 9 CML patients including 4 imatinib-resistant and 5 imatinib-responder patients. Only one differentially expressed miRNA, miR-181c, was found when the imatinib-resistant group was compared with imatinib-responders. Significant down-regulation of miR-181c in imatinib-resistant versus imatinib-responders was confirmed by qRT-PCR.
Drug Response:
resistant
Cancer basic information
Cancer:
chronic myeloid leukemia
Tissue/Cell:
tissue
Other information
Title:
Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia.
Journal:
Mol Cytogenet
Published:
2013
PubMed ID:
23866735