ncRNA basic information
ncRNA ID:
MI0000071
ncRNA Database:
miRBase
ncRNA Name:
miR-17
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
ATG7
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The role of miR-17 in human glioblastoma cells was detected using plasmid constructs and luciferase assay , RIP-Assay, viability and clonogenic survival assays, immunoblotting analysis,Real-time PCR, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
glioblastoma
Tissue/Cell:
cell line (T98G, U373-MG )
Other information
Title:
microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells.
Journal:
Cancer Biol Ther
Published:
2013
PubMed ID:
23792642