ncRNA basic information
ncRNA ID:
MI0000083/MI0000750
ncRNA Database:
miRBase
ncRNA Name:
miR-26a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
MCL-1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name:
Paclitaxel
Drug Method:
The expression levels of miRNA were determined by Quantitative Real-time PCR and those of protein were by Western blot analysis.MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.The cell apoptosis was detected by Annexin V/PI assay. Cell migration was assessed by wound-healing assay.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MDA-MB-231, MCF-7, MDA-MB-435, MDA-MB-468,MCF-10A, 184A1)
Other information
Title:
MiR-26a inhibits proliferation and migration of breast cancer through repression of MCL-1.
Journal:
PLoS One
Published:
2013
PubMed ID:
23750239