ncRNA basic information
ncRNA ID:
MI0000060/MI0000061/MI0000062
ncRNA Database:
miRBase
ncRNA Name:
let-7a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00987 (APRD00499)
Drug Name:
Cytarabine
Drug Method:
The role of let-7a in acute myeloid leukemia was detected using miRNA microarray analysis,RT-PCR, lentiviral constructs and stably transduced cells,flow cytometry, western blot, apoptosis analysis, immunofluorescence staining and confocal microscopy,ChIP assay, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
acute myeloid leukemia
Tissue/Cell:
cell line (OCI-AML3, Molm13 )
Other information
Title:
CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia.
Journal:
J Clin Invest
Published:
2013
PubMed ID:
23676502