ncRNA basic information
ncRNA ID:
MI0000270/MI0000683
ncRNA Database:
miRBase
ncRNA Name:
miR-181b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
MEK1
ncRNA Pathway:
MAPK signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The expression levels of miRNA were determined by real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. The CCK-8 assay was used to monitor the growth of the cells.
Drug Response:
sensitive
Cancer basic information
Cancer:
glioma
Tissue/Cell:
tissue and cell line (U251, U87)
Other information
Title:
miR-181b modulates glioma cell sensitivity to temozolomide by targeting MEK1.
Journal:
Cancer Chemother Pharmacol
Published:
2013
PubMed ID:
23645289