ncRNA basic information
ncRNA ID:
MI0000810
ncRNA Database:
miRBase
ncRNA Name:
miR-135b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
MCL1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. The CCK-8 assay was used to monitor the growth of the cells.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line (A549,A549/CDDP)
Other information
Title:
miR-135a/b modulate cisplatin resistance of human lung cancer cell line by targeting MCL1.
Journal:
Pathol Oncol Res
Published:
2013
PubMed ID:
23640248