ncRNA basic information
ncRNA ID:
MI0000452/MI0000453
ncRNA Database:
miRBase
ncRNA Name:
miR-135a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
MCL1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Quantitative Real-Time PCR and those of protein were by Western blot analysis.Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line (A549,A549/CDDP)
Other information
Title:
miR-135a/b modulate cisplatin resistance of human lung cancer cell line by targeting MCL1.
Journal:
Pathol Oncol Res
Published:
2013
PubMed ID:
23640248