ncRNA basic information
ncRNA ID:
MI0000490
ncRNA Database:
miRBase
ncRNA Name:
miR-206
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
MET
ncRNA Pathway:
PI3K/AKT /mTOR signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Quantitative real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Cell migration was detected by transwell migration and invasion assay. Finally, the effect of mir-206 on cisplatin sensitivity was verified in a mouse model
Drug Response:
sensitive
Cancer basic information
Cancer:
lung adenocarcinoma
Tissue/Cell:
cell line (A549, H1299, A549/DDP, H1299/DDP)
Other information
Title:
miR-206 regulates cisplatin resistance and EMT in human lung adenocarcinoma cells partly by targeting MET.
Journal:
Oncotarget
Published:
2016
PubMed ID:
27014910