ncRNA basic information
ncRNA ID:
MI0000446/MI0000470
ncRNA Database:
miRBase
ncRNA Name:
miR-125b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
p53 and Bak
ncRNA Pathway:
miR-125b-p53/Bak pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00541 (APRD00495)
Drug Name:
Vincristine
Drug Method:
We screened doxorubicin (Dox)-resistant EWS cells to identify any distinct miRNA sequences that may regulate the chemoresistance of EWS cells. The effects of miRNAs were evaluated using a chemosensitivity assay. The possible target genes of the miRNAs were predicted using a web-based prediction program.
Drug Response:
resistant
Cancer basic information
Cancer:
primitive neuroectodermal tumor
Tissue/Cell:
cell line (VH-64, WE-68,SK-N-MC,RD-ES, SK-ES, TC-71 )
Other information
Title:
miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor.
Journal:
Cancer Cell Int
Published:
2013
PubMed ID:
23497288