ncRNA basic information
ncRNA ID:
ENSG00000266835
ncRNA Database:
Ensembl
ncRNA Name:
lncRNA RP11-838N2.4
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The expression levels of lncRNA were determined by quantitative real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of lncRNAs. Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic. TUNEL staining was used to detect apoptotic cell death .
Drug Response:
sensitive
Cancer basic information
Cancer:
glioblastoma
Tissue/Cell:
cell line (U87,U251,U87TR and U251TR )
Other information
Title:
Long noncoding RNA RP11-838N2.4 enhances the cytotoxic effects of temozolomide by inhibiting the functions of miR-10a in glioblastoma cell lines.
Journal:
Oncotarget
Published:
2016
PubMed ID:
27270310