ncRNA basic information
ncRNA ID:
MI0000454
ncRNA Database:
miRBase
ncRNA Name:
miR-137
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
YB-1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00541 (APRD00495)
Drug Name:
Vincristine
Drug Method:
The role of miR-137 in multidrug-resistant MCF-7/ADM cells was detected using microRNA transfection assay,stem-loop reverse transcriptase polymerase chain reaction, drug sensitivity assay,Intracellular ADM concentration analysis,apoptosis assay,dual luciferase activity assay, siRNA transfection assay,Western blot ,etc.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF-7,MCF-7/ADM)
Other information
Title:
miR-137 restoration sensitizes multidrug-resistant MCF-7/ADM cells to anticancer agents by targeting YB-1.
Journal:
Acta Biochim Biophys Sin (Shanghai)
Published:
2013
PubMed ID:
23178914