ncRNA basic information
ncRNA ID:
MI0000735
ncRNA Database:
miRBase
ncRNA Name:
miR-29c
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
Mcl-1 and Bcl-2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Annexin V-FITC/PI apoptosis detection by flow cytometry .
Drug Response:
sensitive
Cancer basic information
Cancer:
nasopharyngeal carcinoma
Tissue/Cell:
cell line ( C666-1, CNE1, CNE2, HONE1, HNE2, 5-8F, SUNE1,6-10B)
Other information
Title:
MicroRNA-29c enhances the sensitivities of human nasopharyngeal carcinoma to cisplatin-based chemotherapy and radiotherapy.
Journal:
Cancer Lett
Published:
2013
PubMed ID:
23142283