ncRNA basic information
ncRNA ID:
MI0000457
ncRNA Database:
miRBase
ncRNA Name:
miR-141
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
KEAP1
ncRNA Pathway:
NF-kappaB pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
We compared miRNA expression profiles of an isogenic cisplatin-sensitive and -resistant ovarian cancer cell line to found the different expressed level.The expression levels of miRNA were determined by RT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line (A2780, A2780 DDP)
Other information
Title:
miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells.
Journal:
Oncogene
Published:
2013
PubMed ID:
23045278