ncRNA basic information
ncRNA ID:
MI0003138
ncRNA Database:
miRBase
ncRNA Name:
miR-497
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
IGF1R
ncRNA Pathway:
MEK/ERK signalling pathway,PI3K/Akt pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The role of miR-497 in human colorectal cancer cells was detected using miR microarray, Quantitative reverse transcription and real-time PCR analysis,array comparative genomic hybridization, plasmid vectors and transfection,small RNA interference, luciferase reporter assays,western blot analysis,matrigel invasion assays,etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
colorectal cancer
Tissue/Cell:
tissue and cell line (HCT116, HCT28, LoVo, Colon205, SW480, SW620)
Other information
Title:
MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer.
Journal:
Oncogene
Published:
2013
PubMed ID:
22710713