ncRNA basic information
ncRNA ID:
MIMAT0000686
ncRNA Database:
miRBase
ncRNA Name:
miR-34c-5p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qt-RT-PCR
ncRNA Target Gene:
Bmf
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name:
Paclitaxel
Drug Method:
The expression levels of miRNA were determined by qt-RT-PCR . Those of protein were by Immunoprecipitation and immunoblotting . Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line (A549, H460,A549-FK )
Other information
Title:
miR-34c may protect lung cancer cells from paclitaxel-induced apoptosis.
Journal:
Oncogene
Published:
2013
PubMed ID:
22370637