ncRNA basic information
ncRNA ID:
MI0000681
ncRNA Database:
miRBase
ncRNA Name:
miR-155
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
SMAD2,TCF4 and CCND1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by real-time PCR and those of protein were by Western blot analysis.MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Cell migration was detected by migration and invasion assay. Flow cytometry analysis was used to determine the distribution of cells in cell cycle sub-phases and to measure the apoptosis peak induced by DDP (10 mol/ml) for 24 hours.
Drug Response:
sensitive
Cancer basic information
Cancer:
cervical cancer
Tissue/Cell:
cell line
Other information
Title:
Up-regulated miR155 reverses the epithelial-mesenchymal transition induced by EGF and increases chemo-sensitivity to cisplatin in human Caski cervical cancer cells.
Journal:
PLoS One
Published:
2012
PubMed ID:
23284982