ncRNA basic information
ncRNA ID:
MI0000650
ncRNA Database:
miRBase
ncRNA Name:
miR-200c
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
TUBB3
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name:
Paclitaxel
Drug Method:
The role of miR-200c in ovarian cancer cells was detected using western blot, anoikis assays,MTT assay, cell-adhesion assay,qRT-PCR, bioluminescent assays, ovarian tumor xenograft and luminescent imaging in mice,Immunohistochemistry, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line (HEY, SKOV3, OVCA 420, OV 1847, OVCA 433)
Other information
Title:
Restoration of miR-200c to ovarian cancer reduces tumor burden and increases sensitivity to paclitaxel.
Journal:
Mol Cancer Ther
Published:
2012
PubMed ID:
23074172