ncRNA basic information
ncRNA ID:
MI0000650
ncRNA Database:
miRBase
ncRNA Name:
miR-200c
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01248 (APRD00932)
Drug Name:
Docetaxel
Drug Method:
The expression levels of miRNA were determined by RT-qPCR and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Cell migration was detected by migration and invasion assay.
Drug Response:
resistant
Cancer basic information
Cancer:
prostate cancer
Tissue/Cell:
cell line ( PC3, DU-145,PC3-DR, DU-145-DR,HBMEC-60)
Other information
Title:
Epithelial-to-mesenchymal transition leads to docetaxel resistance in prostate cancer and is mediated by reduced expression of miR-200c and miR-205.
Journal:
Am J Pathol
Published:
2012
PubMed ID:
23041061