ncRNA basic information
ncRNA ID:
ENSG00000229807
ncRNA Database:
Ensembl
ncRNA Name:
XIST
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
DNA mismatch repair pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The expression levels of lncRNA were determined by Real-time PCR and those of protein were by Western blot analysis. Fuciferase activity assay was used to verify the target genes of miRNAs.MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
glioma
Tissue/Cell:
tissue and cell line (U251, U373, LN229, U118, and LN229)
Other information
Title:
LncRNA-XIST interacts with miR-29c to modulate the chemoresistance of glioma cell to TMZ through DNA mismatch repair pathway.
Journal:
Biosci Rep
Published:
2017
PubMed ID:
28831025