ncRNA basic information
ncRNA ID:
MI0000681
ncRNA Database:
miRBase
ncRNA Name:
miR-155
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
Real-time RT-PCR
ncRNA Target Gene:
Apaf-1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The role of miR-155 in lung cancer cells was detected using plasmid construction of Apaf-1-pcDNA3.1, Cell transfection,western blot analysis,Real-time RT-PCR, single cell gel electrophoresis (comet assay), analysis of cellular apoptosis .etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line (A549)
Other information
Title:
MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expression.
Journal:
Cancer Gene Ther
Published:
2012
PubMed ID:
22996741