ncRNA basic information
ncRNA ID:
MI0000284
ncRNA Database:
miRBase
ncRNA Name:
miR-204
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
Quantitative real-time RT-PCR
ncRNA Target Gene:
BCL2 and NTRK2
ncRNA Pathway:
PI3K/AKT pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
Neuroblastoma cell lines were transiently transfected with miR-204 mimics and assessed for cell viability using MTS assays. Apoptosis levels in cell lines were evaluated by FACS analysis of Annexin V-/propidium iodide-stained cells transfected with miR-204 mimics and treated with chemotherapy drug or vehicle control. Potential targets of miR-204 were validated using luciferase reporter assays.
Drug Response:
sensitive
Cancer basic information
Cancer:
neuroblastoma
Tissue/Cell:
cell line (Kelly,SK-N-AS,SHSY-5Y,NB1691)
Other information
Title:
MicroRNA-204 increases sensitivity of neuroblastoma cells to cisplatin and is associated with a favourable clinical outcome.
Journal:
Br J Cancer
Published:
2012
PubMed ID:
22892391