ncRNA basic information
ncRNA ID:
MI0000064
ncRNA Database:
miRBase
ncRNA Name:
Let-7c
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
IL-6/STAT3 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
Using pretreatment biopsy samples from 98 patients with esophageal cancer who received preoperative chemotherapy, we measured the expression level of several miRNAs whose expression was altered in cisplatin-resistant esophageal cancer cell lines compared with those parent cell lines and examined the relationship between the miRNA expression and response to chemotherapy. In vitro assays were conducted to clarify the mechanism of miRNA-induced changes in chemosensitivity.
Drug Response:
sensitive
Cancer basic information
Cancer:
esophageal squamous cell carcinoma
Tissue/Cell:
cell line (TE1,TE5,TE8,TE9,TE10,TE11,TE13)
Other information
Title:
Let-7 expression is a significant determinant of response to chemotherapy through the regulation of IL-6/STAT3 pathway in esophageal squamous cell carcinoma.
Journal:
Clin Cancer Res
Published:
2012
PubMed ID:
22847808