ncRNA basic information
ncRNA ID:
MI0000446/MI0000470
ncRNA Database:
miRBase
ncRNA Name:
miR-125b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
E2F3
ncRNA Pathway:
p53 signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00544 (APRD00516, EXPT03204)
Drug Name:
Fluorouracil
Drug Method:
Circulating miRNAs in blood serum prior to treatment were determined by quantitative Real-Time PCR in 56 breast cancer patients with invasive ductal carcinoma and pre-operative neoadjuvant chemotherapy. Proliferating cell nuclear antigen (PCNA) immunostaining and TUNEL were performed in surgical samples to determine the effects of chemotherapy on cancer cell proliferation and apoptosis, respectively.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF-7, T47D, BT20, MDA-MB-231)
Other information
Title:
Circulating MiR-125b as a marker predicting chemoresistance in breast cancer.
Journal:
PLoS One
Published:
2012
PubMed ID:
22523546