ncRNA basic information
ncRNA ID:
MI0000242/MI0000281
ncRNA Database:
miRBase
ncRNA Name:
miR-199a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
CD44
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined byquantitative real-time PCR and Northern blotting . those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.Cell migration was detected by transwell migration . IF staining analysis for relative protein expression.
Drug Response:
sensitive
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line (CD44+/CD117+)
Other information
Title:
MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells.
Journal:
FEBS J
Published:
2012
PubMed ID:
22498306