ncRNA basic information
ncRNA ID:
MI0000088
ncRNA Database:
miRBase
ncRNA Name:
miR-30a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
ATG5
ncRNA Pathway:
mitochondria-dependent intrinsic apoptotic pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00619 (APRD01028, EXPT02967, DB03261)
Drug Name:
Imatinib
Drug Method:
The expression levels of miRNA were determined by qRT-PCR and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
chronic myeloid leukemia
Tissue/Cell:
cell line (K562)
Other information
Title:
Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells.
Journal:
Leukemia
Published:
2012
PubMed ID:
22395361