ncRNA basic information
ncRNA ID:
MI0000727
ncRNA Database:
miRBase
ncRNA Name:
miR-128-2
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
E2F5
ncRNA Pathway:
PI3K/Akt pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line (H1299, H1299 clone 41, H1299 clone 23 and H1299 clone pIND )
Other information
Title:
MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function.
Journal:
Cell Death Differ
Published:
2012
PubMed ID:
22193543