ncRNA basic information
ncRNA ID:
NA
ncRNA Database:
miRBase
ncRNA Name:
miR-17-92
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
Real-time RT-PCR
ncRNA Target Gene:
PHLPP2
ncRNA Pathway:
PI3K/AKT pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
Gene expression profiling was performed on 92 patients with cyclin D1-positive MCL.The expression levels of miRNA were determined by real time RT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. A xenograft MCL mouse model was used to identify the relationship between miR-17-92 cluster and drug resistant .
Drug Response:
resistant
Cancer basic information
Cancer:
mantle cell lymphoma
Tissue/Cell:
cell line ( Z138c, Granta-519, Jeko-1,HEK293T and NIH3T3)
Other information
Title:
The miRNA-17-92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation.
Journal:
Leukemia
Published:
2012
PubMed ID:
22116552