ncRNA basic information
ncRNA ID:
MI0000650
ncRNA Database:
miRBase
ncRNA Name:
miR-200c
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
Real-time RT-PCR
ncRNA Target Gene:
MDR1
ncRNA Pathway:
EMT and p53 apoptotic pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined by Real-time RT-PCR . MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF-7,MCF-7/ADR)
Other information
Title:
Down-regulation of microRNA-200c is associated with drug resistance in human breast cancer.
Journal:
Med Oncol
Published:
2012
PubMed ID:
22101791