ncRNA basic information
ncRNA ID: MI0000748
ncRNA Database: miRBase
ncRNA Name: miR-130b
ncRNA Type: miRNA
ncRNA Expression: up-regulated
ncRNA Method: qRT-PCR
ncRNA Target Gene: CSF-1
ncRNA Pathway: NA
Evidence (ncRNA-drug): validated
drug basic information
Drug ID: DB00515 (APRD00359)
Drug Name: Cisplatin
Drug Method: The expression of miR-130b was assessed in ovarian tissues and cell lines by qRT-PCR. In vitro, miR-130b level was manipulated by transfection with mimics or inhibitors. Methylation level of miR-130b was evaluated by quantitative methylation-specific PCR (qMSP). CSF-1 expression in ovarian tissues and cells was determined by qRT-PCR, immunohistochemistry and ELISA, respectively. CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system.
Drug Response: sensitive
Cancer basic information
Cancer: ovarian cancer
Tissue/Cell: tissue and cell line
Other information
Title: Epigenetic silencing of miR-130b in ovarian cancer promotes the development of multidrug resistance by targeting colony-stimulating factor 1.
Journal: Gynecol Oncol
Published: 2012
PubMed ID: 22005523